The project originated as part of the Complementary National Plan (PNC), which has a specific focus on Health, Environment, Biodiversity and Climate. D³4 Health, in particular, promotes research in the area of Health, through the development of digital technologies and data mining approaches, applied to the treatment of 5 main diseases: metastatic colon cancer, liver and bile duct cancer, central nervous system cancer, diabetes type I and multiple sclerosis. Specifically, the project aims to develop digital and biological twins for the diagnosis, monitoring and treatment of these five benchmark diseases, through the collection of health data analyzed by artificial intelligence-powered algorithms, collected on a multilayer platform and also obtained through the development and use of innovative technologies such as wearable devices, sensors and biomarkers. The D³4 Health Foundation, established to manage the project, consists of 28 partners including public and private universities, research institutes and companies, with Prof. Maria Sabrina Sarto being the President. Sapienza University of Rome is the project leader, and the scientific contact person is Prof. Carlo Catalano, (This email address is being protected from spambots. You need JavaScript enabled to view it.). The project is also a great opportunity for young researchers to be part of an R&D program aimed at health system innovation through the digital technology transition, where Research and Business come together to jointly promote and support high-level research, technology transfer and higher education. The participation to the Nanoinnovation 2024 will represent an opportunity to showcase cutting-edge activities, to network with leading experts in the field, and explore potential collaborations with other pioneering research initiatives, fostering interdisciplinary collaborations and drive forward the integration of nanotechnology and digital health solutions.